Treatment of lymphoblastic lymphomas in children in Russia: preliminary results of a multicenter retrospective study

E. V. Volchkov; Волчков Егор Васильевич; T. Yu. Pavlova; Павлова Татьяна Юрьевна; G. I. Shestopalov; Шестопалов Глеб Игоревич; L. S. Zubarovskaya; Зубаровская Людмила Степановна; A. V. Protsvetkina; Процветкина Анастасия Владимировна; E. A. Burtsev; Бурцев Евгений Андреевич; D. S. Abramov; Абрамов Дмитрий Сергеевич; G. R. Kazaryan; Казарян Гузель Рафаиловна; V. V. Martynenko; Мартыненко Валерия Викторовна; K. A. Tsytsylina; Цыцылина Кристина Александровна; V. O. Stepanova; Степанова Вероника Олеговна; Yu. E. Belkina; Белкина Юлия Евгеньевна; V. A. Myasnikova; Мясникова Виолетта Александровна; N. A. Danilyuk; Данилюк Наталья Александровна; V. E. Tulyavko; Тулявко Влада Евгеньевна; I. Y. Oleynik; Олейник Ирина Юрьевна; D. K. Polosukhina; Полосухина Дарья Константиновна; I. A. Loskutov; Лоскутов Иван Алексеевич; O. P. Oleshchuk; Олещук Оксана Петровна; R. O. Panko; Панько Родион Олегович; G. V. Bykova; Быкова Галина Витальевна; O. P. Tolmacheva; Толмачева Ольга Петровна; D. N. Koroleva; Королева Дарья Николаевна; S. V. Mkrtchyan; Мкртчян Сюзанна Валерьевна; M. S. Yudakova; Юдакова Марина Сергеевна; M. B. Belogurova; Белогурова Маргарита Брисовна; T. T. Valiev; Валиев Тимур Теймуразович; N. V. Myakova; Мякова Наталья Валерьевна

doi:10.17650/1818-8346-2026-21-1-10-21

Treatment of lymphoblastic lymphomas in children in Russia: preliminary results of a multicenter retrospective study

Authors: Volchkov E.V.¹^,2, Pavlova T.Y.³, Shestopalov G.I.⁴, Zubarovskaya L.S.⁵, Protsvetkina A.V.¹, Burtsev E.A.⁶, Abramov D.S.¹, Kazaryan G.R.⁷, Martynenko V.V.⁸, Tsytsylina K.A.⁹, Stepanova V.O.¹⁰, Belkina Y.E.¹¹, Myasnikova V.A.¹², Danilyuk N.A.¹³, Tulyavko V.E.¹⁴, Oleynik I.Y.¹⁵, Polosukhina D.K.¹⁶, Loskutov I.A.¹⁷, Oleshchuk O.P.¹⁸, Panko R.O.¹⁹, Bykova G.V.²⁰, Tolmacheva O.P.²¹, Koroleva D.N.²², Mkrtchyan S.V.²³, Yudakova M.S.²⁴, Belogurova M.B.²⁵, Valiev T.T.³^,26, Myakova N.V.¹
Affiliations:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia
2. Botkin Hospital, Moscow Healthcare Department
3. N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
4. Russian Children’s Clinical Hospital – branch of the N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
5. I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
6. Morozov Children’s Municipal Clinical Hospital, Moscow Healthcare Department
7. Nizhnevartovsk District Clinical Hospital
8. Bryansk Regional Children’s Hospital
9. Children’s Regional Clinical Hospital, Ministry of Health of Krasnodar Region
10. Moscow Regional Oncology Dispensary
11. Republican Children’s Clinical Hospital, Simferopol
12. Chelyabinsk Regional Children’s Clinical Hospital
13. Regional Oncology Clinical Dispensary, Penza
14. RUDN University
15. Tomsk Regional Clinical Hospital
16. Volgograd Regional Clinical Oncology Dispensary
17. Regional Children’s Clinical Hospital No. 1, Vladivostok
18. A.K. Piotrovich Children’s Regional Clinical Hospital
19. Samara Regional Children’s Clinical Hospital named after N. N. Ivanova
20. Children’s Regional Clinical Hospital, Stavropol
21. Irkutsk State Regional Children’s Clinical Hospital
22. Republican Children’s Clinical Hospital, Ministry of Health of Republic of Udmurtia
23. Ulyanovsk Regional Children’s Clinical Hospital named after political and public figure Yu.F. Goryachev
24. Regional Children’s Clinical Hospital named after N. V. Dmitrieva
25. Saint-Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncology) named after N. P. Napalkov
26. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Issue: Vol 21, No 1 (2026)
Pages: 10-21
Section: HEMATOLOGIC MALIGNANCIES: TREATMENT
Published: 23.03.2026
URL: https://oncohematology.eco-vector.com/ongm/article/view/1043
DOI: https://doi.org/10.17650/1818-8346-2026-21-1-10-21
ID: 1043

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Abstract
About the authors
References
Supplementary files
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Abstract

Background. Lymphoblastic lymphomas (LBL) are an aggressive variant of non-Hodgkin’s lymphomas (NHL), which ranks second in frequency among non-Hodgkin’s lymphomas in children. According to international data, the effectiveness of LBL therapy in children reaches 85 %. In Russia, information on the treatment results for this disease is extremely limited.

Aim. To present preliminary data on the results of LBL therapy in children in Russia.

Materials and methods. The study included 392 pediatric LBL patients, treated in 57 specialized hospitals of the Russian Federation from 1999 to 2024.

Results. The overall and event-free survival rates were 83 % (95 % confidence interval 78–88) and 70 % (95 % confidence interval 64–78), respectively. In addition, the analysis revealed a high frequency of thrombotic complications (29 % of all patients), especially in cases of T-cell LBL. No significant differences in disease outcomes were found between tumor immunophenotypes, the type of asparaginase, and the stage of the disease. A separate analysis of the results of LBL therapy according to the ALL IC-BFM 2002 / 2009 protocols (146 patients) with stricter criteria for the response to induction therapy (tumor reduction of more than 70 %) and early chemotherapy intensification with high-dose blocks at the N. N. Blokhin National Medical Research Center of Oncology showed the event-free and overall survival of about 90 %. The Cox regression model of the dependence of therapy outcomes on residual tumor volume at the end of induction in the main cohort of patients did not reveal an association between residual tumor volume and overall survival (p = 0.2), but there was a statistical association with event-free survival (p = 0.006).

Discussion. This paper presents preliminary data from the first multicenter study of LBL therapy in pediatric patients in the Russian Federation. According to our data, LBL survival rates in the Russia should be improved. An important problem in the treatment of LBL in children is therapy complications, especially the high incidence of thrombosis. In this regard, anticoagulant prophylaxis is recommended for patients with LBL, especially with the T-cell phenotype and the presence of risk factors. Further studies are also needed to identify high-risk patients for the development of new personalized therapy approaches.

Conclusion. The paper presents preliminary results from the first multicenter clinical study of LBL therapy in children in Russia, indicating the necessity of treatment approaches improvement for increase a treatment effectiveness.

Keywords

lymphoblastic lymphomas, non-Hodgkin’s lymphomas, children, adolescents, Berlin–Frankfurt–Muenster protocol, thrombosis

About the authors

E. V. Volchkov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Botkin Hospital, Moscow Healthcare Department

Author for correspondence.
Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-2574-1636
Russian Federation, 1 Samory Mashela St., Moscow 117198; ; 5 2nd Botkinskiy Proezd, Moscow 125284

T. Yu. Pavlova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: md.pavlovaty@mail.ru
ORCID iD: 0000-0003-4999-5195
Russian Federation, 23 Kashirskoe Shosse, Moscow 115522

G. I. Shestopalov

Russian Children’s Clinical Hospital – branch of the N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-2410-2867
Russian Federation, 117 Leninskiy Prospekt, Moscow 119571

L. S. Zubarovskaya

I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0003-2594-7703

Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation

Russian Federation, 6–8 L’va Tolstogo St., Saint Petersburg 197022

A. V. Protsvetkina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

Email: a.procvetkina@dgoi.ru
Russian Federation, 1 Samory Mashela St., Moscow 117198

E. A. Burtsev

Morozov Children’s Municipal Clinical Hospital, Moscow Healthcare Department

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-3623-6547
Russian Federation, 1 / 9 4th Dobryninskiy Pereulok, Moscow 119049

D. S. Abramov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0003-3664-2876
Russian Federation, 1 Samory Mashela St., Moscow 117198

G. R. Kazaryan

Nizhnevartovsk District Clinical Hospital

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-1881-7444
Russian Federation, 19 Marshala Zhukova St., Nizhnevartovsk 628616

V. V. Martynenko

Bryansk Regional Children’s Hospital

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0001-5203-7815
Russian Federation, 100 Stanke Dimitrova Prospekt, Bryansk 241050

K. A. Tsytsylina

Children’s Regional Clinical Hospital, Ministry of Health of Krasnodar Region

Email: volchcov.egor@yandex.ru
Russian Federation, 1 Ploshchad’ Pobedy, 350007 Krasnodar

V. O. Stepanova

Moscow Regional Oncology Dispensary

Email: v.o.stepanova@yandex.ru
Russian Federation, 6 Karbysheva St., Balashikha 143900

Yu. E. Belkina

Republican Children’s Clinical Hospital, Simferopol

Email: volchcov.egor@yandex.ru
ORCID iD: 0000-0002-4936-5719
Russian Federation, 71 Titova St, Simferopol 295034

V. A. Myasnikova

Chelyabinsk Regional Children’s Clinical Hospital

Email: volchcov.egor@yandex.ru
Russian Federation, 42A Blukhera St., Chelyabinsk 454087

N. A. Danilyuk

Regional Oncology Clinical Dispensary, Penza

Email: volchcov.egor@yandex.ru
Russian Federation, 37A Stroiteley Prospekt, Penza 440071

V. E. Tulyavko

RUDN University

Email: volchcov.egor@yandex.ru

Research Institute of Molecular and Cellular Medicine

Russian Federation, 8 Podolskoe Shosse, Moscow 115093

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